Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.

The Journal of biological chemistry - 28 Nov 2003

Leung Laura, Kwong Mandy, Hou Stephen, Lee Candy, Chan Jefferson Y

Abstract excerpt

Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and they are co-expressed in a wide range of tissues during development. Nrf2 has been shown to be dispensable for growth and development in mice. Nrf2-deficient mice, however, are impa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Blotting, Northern
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to NF-E2-Related Factor 2

Share to Proto-Oncogene Proteins c-bcl-2

Share to Reactive Oxygen Species

Source

Identifiers

PMID: 12968018
DOI: 10.1074/jbc.M308439200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12968018-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.PMID 12968018Read ↗

A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene.Semantic proximity Read ↗

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.Semantic proximity Read ↗

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human DiseaseSemantic proximity Read ↗

Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity.Semantic proximity Read ↗

Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress.Semantic proximity Read ↗

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integritySemantic proximity Read ↗

Nrf2-Keap1 defines a physiologically important stress response mechanism.Semantic proximity Read ↗

The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development.Semantic proximity Read ↗

Nrf2 at the heart of oxidative stress and cardiac protectionSemantic proximity Read ↗

Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models.Semantic proximity Read ↗

Functional polymorphisms in Nrf2: implications for human disease.Semantic proximity Read ↗

Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.