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Article

Midkine Promotes Neuroblastoma through Notch2 Signaling

15 Dec 2012

Abstract excerpt

Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma in which MYCN is amplified remains particularly poor. In this study, we used a MYCN transgenic model for neuroblastoma in which midkine is highly expressed in precancerous lesions of sympathetic ganglia. Genetic...

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PMID: 23243020
DOI: 10.1158/0008-5472.can-12-3070

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