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Article

Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome.

The Journal of general virology - 1 Jun 1992

Roemer K, Johnson P A, Friedmann T

Abstract excerpt

We have used a vector derived from a herpes simplex virus type 1 (HSV-1) mutant deleted for 3.6 kbp of the essential immediate early gene 3 to transduce the Tn5 neomycin phosphotransferase (neor) gene into rodent and primate cells in culture. The transgene was flanked by genomic sequences from the human hprt gene. We demonstrate in this study that sequences introduced by infection with the replication-defective...

Topics

Animals
Blotting, Southern
Cell Line
Defective Viruses
Drug Resistance
Humans
Immediate-Early Proteins
Kanamycin Kinase
Mutation
Phosphotransferases
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Viral Proteins

Virus Integration

Source

Identifiers

PMID: 1318949
DOI: 10.1099/0022-1317-73-6-1553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1318949-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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