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Substitution mutations affecting a small region of the Moloney murine leukemia virus MA gag protein block assembly and release of virion particles.

Virology - 15 Nov 1994

Granowitz C, Goff S P

Abstract excerpt

A series of substitution mutations affecting the Moloney murine leukemia virus MA protein were introduced into a cloned proviral DNA, and the mutant DNAs were tested for their biological activity in NIH/3T3 cells and COS cells. Many of the mutant viruses were viable and replicated with kinetics indistinguishable from the wild type. Seven mutants with alterations in a small region (residues 7-14 from the amino...

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PMID: 7975229
DOI: 10.1006/viro.1994.1650

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