Substitution mutations affecting a small region of the Moloney murine leukemia virus MA gag protein block assembly and release of virion particles.

doi:10.1006/viro.1994.1650

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Article

Substitution mutations affecting a small region of the Moloney murine leukemia virus MA gag protein block assembly and release of virion particles.

Virology - 15 Nov 1994

Granowitz C, Goff S P

Abstract excerpt

A series of substitution mutations affecting the Moloney murine leukemia virus MA protein were introduced into a cloned proviral DNA, and the mutant DNAs were tested for their biological activity in NIH/3T3 cells and COS cells. Many of the mutant viruses were viable and replicated with kinetics i...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Cell Line
DNA, Viral
Gene Products, gag
Gene Products, pol
Genes, gag
Mice
Molecular Sequence Data
Moloney murine leukemia virus
Mutation
Virus Replication

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