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Article

Coronaviruses Maintain Viability despite Dramatic Rearrangements of the Strictly Conserved Genome Organization

18 Nov 2002

Abstract excerpt

Despite their high frequency of RNA recombination, the plus-strand coronaviruses have a characteristic, strictly conserved genome organization with the essential genes occurring in the order 5'-polymerase (pol)-S-E-M-N-3'. We have investigated the significance of this remarkable conservation by rearrangement of the murine coronavirus genome through targeted recombination. Thus, viruses were prepared with the...

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PMID: 12438575
DOI: 10.1128/jvi.76.24.12491-12502.2002

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