Article
Murine cytomegalovirus encodes a stable intron that facilitates persistent replication in the mouse.
Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2006
Kulesza Caroline A, Shenk Thomas
Abstract excerpt
The human cytomegalovirus immediate-early 5-kb RNA previously has been shown to be a stable intron that is not required for efficient replication of the virus in cultured fibroblasts. Here we describe a murine cytomegalovirus 7.2-kb ortholog of the human cytomegalovirus 5-kb RNA. The 5' end of the 7.2-kb transcript maps to a consensus splice-donor site that is conserved among all cytomegaloviruses. We constructed...
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