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RNA Recombination In Vivo in the Absence of Viral Replication

26 May 2004

Abstract excerpt

To study fundamental aspects of RNA recombination, an in vivo RNA recombination system was established. This system allowed the efficient generation of recombinant cytopathogenic pestiviruses after transfection of synthetic, nonreplicatable, subgenomic transcripts in cells infected with a replicating noncytopathogenic virus. Studies addressing the interplay between RNA recombination and replication revealed that...

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Identifiers

PMID: 15163720
DOI: 10.1128/jvi.78.12.6271-6281.2004

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