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Article

Reversion of a Moloney murine leukemia virus RNase H mutant at a second site restores enzyme function and infectivity.

Journal of virology - 1 Aug 1995

Blain S W, Hendrickson W A, Goff S P

Abstract excerpt

The reverse transcriptase of retroviruses contains an RNase H activity essential for the proper synthesis of the viral DNA copy of the RNA genome. We have previously characterized a number of point mutations altering the RNase domain of the Moloney murine leukemia virus reverse transcriptase (S. W. Blain and S. P. Goff, J. Biol. Chem. 268:23585-23592, 1993). One such mutation, Y586F (a Y-to-F change at position...

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Identifiers

PMID: 7541847
DOI: 10.1128/JVI.69.8.5113-5116.1995
PMCID: PMC189329

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