Reversion of a Moloney murine leukemia virus RNase H mutant at a second site restores enzyme function and infectivity.

doi:10.1128/JVI.69.8.5113-5116.1995

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Article

Reversion of a Moloney murine leukemia virus RNase H mutant at a second site restores enzyme function and infectivity.

Journal of virology - 1 Aug 1995

Blain S W, Hendrickson W A, Goff S P

Abstract excerpt

The reverse transcriptase of retroviruses contains an RNase H activity essential for the proper synthesis of the viral DNA copy of the RNA genome. We have previously characterized a number of point mutations altering the RNase domain of the Moloney murine leukemia virus reverse transcriptase (S....

Topics

Base Sequence
Cell Line
DNA
DNA Primers
Hydrolysis
Molecular Sequence Data
Moloney murine leukemia virus
Mutation
Protein Conformation
RNA
Ribonuclease H

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