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Article

Analysis of mutations in the envelope gene of Moloney murine leukemia virus: separation of infectivity from superinfection resistance.

Virology - 1 Aug 1991

Granowitz C, Colicelli J, Goff S P

Abstract excerpt

Six deletion mutations and an insertion were generated in the env gene of cloned copies of Moloney murine leukemia virus DNA. All seven mutants were replication-defective as tested by transformation of NIH/3T3 cells. The mutant DNAs were introduced into NIH/3T3 cells to generate stable producer lines; all released virion particles into the medium, suggesting that none of the mutations affected overall viral gene...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Transport
Cell Line
Cell Transformation, Viral
Cloning, Molecular
DNA, Viral
Electrophoresis, Polyacrylamide Gel
Genes, env
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Moloney murine leukemia virus

Mutation

Viral Envelope Proteins

Virus Replication

Source

Identifiers

PMID: 1853560
DOI: 10.1016/0042-6822(91)90983-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1853560-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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