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Evolutionary Transition toward Defective RNAs That Are Infectious by Complementation

12 Oct 2004

Abstract excerpt

Passage of foot-and-mouth disease virus (FMDV) in cell culture resulted in the generation of defective RNAs that were infectious by complementation. Deletions (of nucleotides 417, 999, and 1017) mapped in the L proteinase and capsid protein-coding regions. Cell killing followed two-hit kinetics, defective genomes were encapsidated into separate viral particles, and individual viral plaques contained defective...

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Identifiers

PMID: 15479809
DOI: 10.1128/jvi.78.21.11678-11685.2004

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