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Article

Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation.

European journal of immunology - 1 Mar 2014

Caton Andrew J, Kropf Elizabeth, Simons Donald M, Aitken Malinda, Weissler Katherine A, Jordan Martha S

Abstract excerpt

Autoreactive CD4(+) CD8(-) (CD4SP) thymocytes can be subjected to deletion when they encounter self-peptide during their development, but they can also undergo selection to become CD4SPFoxp3(+) Treg cells. We have analyzed the relationship between these distinct developmental fates using mice in which signals transmitted by the TCR have been attenuated by mutation of a critical tyrosine residue of the adapter...

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PMID: 24307208
DOI: 10.1002/eji.201343767
PMCID: PMC3959276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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