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Article

Beyond DNA Repair: DNA-PK Function in Cancer

29 Aug 2014

Abstract excerpt

UNLABELLED: The DNA-dependent protein kinase (DNA-PK) is a pivotal component of the DNA repair machinery that governs the response to DNA damage, serving to maintain genome integrity. However, the DNA-PK kinase component was initially isolated with transcriptional complexes, and recent findings have illuminated the impact of DNA-PK-mediated transcriptional regulation on tumor progression and therapeutic response....

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PMID: 25168287
DOI: 10.1158/2159-8290.cd-14-0358

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