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Targeting DNA Double-Strand Break (DSB) Repair to Counteract Tumor Radio-resistance

26 Feb 2019

Abstract excerpt

During the last decade, advances of radiotherapy (RT) have been made in the clinical practice of cancer treatment. RT exerts its anticancer effect mainly via leading to the DNA Double-Strand Break (DSB), which is one of the most toxic DNA damages. Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR) are two major DSB repair pathways in human cells. It is known that dysregulations of DSB repair...

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PMID: 30806313
DOI: 10.2174/1389450120666190222181857

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