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Article

Contribution of selection for protein folding stability in shaping the patterns of polymorphisms in coding regions.

Molecular biology and evolution - 1 Jan 2014

Serohijos Adrian W R, Shakhnovich Eugene I

Abstract excerpt

The patterns of polymorphisms in genomes are imprints of the evolutionary forces at play in nature. In particular, polymorphisms have been extensively used to infer the fitness effects of mutations and their dynamics of fixation. However, the role and contribution of molecular biophysics to these observations remain unclear. Here, we couple robust findings from protein biophysics, enzymatic flux theory, the...

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Identifiers

PMID: 24124208
DOI: 10.1093/molbev/mst189
PMCID: PMC3879451

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