Article
Mutation bias favors protein folding stability in the evolution of small populations.
PLoS computational biology - 6 May 2010
Mendez Raul, Fritsche Miriam, Porto Markus, Bastolla Ugo
Abstract excerpt
Mutation bias in prokaryotes varies from extreme adenine and thymine (AT) in obligatory endosymbiotic or parasitic bacteria to extreme guanine and cytosine (GC), for instance in actinobacteria. GC mutation bias deeply influences the folding stability of proteins, making proteins on the average less hydrophobic and therefore less stable with respect to unfolding but also less susceptible to misfolding and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.