Article
A first-principles model of early evolution: emergence of gene families, species, and preferred protein folds.
PLoS computational biology - 1 Jul 2007
Zeldovich Konstantin B, Chen Peiqiu, Shakhnovich Boris E, Shakhnovich Eugene I
Abstract excerpt
In this work we develop a microscopic physical model of early evolution where phenotype--organism life expectancy--is directly related to genotype--the stability of its proteins in their native conformations-which can be determined exactly in the model. Simulating the model on a computer, we cons...
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