Article
Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2.
Cell cycle (Georgetown, Tex.) - 1 Oct 2012
Chen Ping-Hung, Chien Fan-Ching, Lee Sue-Ping, Chan Woan-Eng, Lin I-Hsuan, Liu Chun-Shan, Lee Fang-Jen, Lai Jiann-Shiun, Chen Peilin, Yang-Yen Hsin-Fang, Yen Jeffrey Jong-Young
Abstract excerpt
It is well known that ligand binding to the high-affinity GM-CSF receptor (GMR) activates JAK2. However, how and where this event occurs in a cellular environment remains unclear. Here, we demonstrate that clathrin- but not lipid raft-mediated endocytosis is crucial for GMR signaling. Knockdown expression of clathrin heavy chain or intersectin 2 (ITSN2) attenuated GMR-mediated activation of JAK2, whereas...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.