Article
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.
Cellular signalling - 1 Jul 2017
Bongartz Hannes, Hessenkemper Wiebke, Müller Christian, Fensky Melissa, Fritsch Johannes, Mandel Katharina, Behrmann Iris, Haan Claude, Fischer Thomas, Feller Stephan M, Schaper Fred
Abstract excerpt
The constitutively active Janus kinase 2 mutant Jak2-V617F is responsible for cytokine-independent growth of hematopoietic cells and the development of myeloproliferative neoplasms, such as polycythaemia vera and essential thrombocythaemia. Cells expressing Jak2-V617F exhibit constitutive STAT, MAPK, and PI3K signalling, and constitutive association of the multi-site docking protein Gab1 to PIP3 at the plasma...
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