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Genetic causes of Parkinson's disease and their links to autophagy regulation.

Parkinsonism & related disorders - 1 Jan 2014

Pan Ping-Yue, Yue Zhenyu

Abstract excerpt

Genetic studies over the past 15 years have revolutionized our understanding towards the etiology of Parkinson's disease (PD). These studies have discovered many disease-linked genetic loci (PARK 1 to 18), which are now being interrogated for cellular pathways contributing to PD. Various pathogenic pathways were proposed but validation of each pathway awaits rigorous experimental testing. Here we review recent...

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alpha-Synuclein
Autophagy
Autophagy in Disease and Therapy
Genetic Predisposition to Disease
Lysosomal Storage Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

Parkinson's Disease Mechanisms and Treatments

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PMID: 24262170
DOI: 10.1016/S1353-8020(13)70037-3

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