Article
A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population.
BMC cancer - 20 Jul 2009
Palomba Grazia, Loi Angela, Uras Antonella, Fancello Patrizia, Piras Giovanna, Gabbas Attilio, Cossu Antonio, Budroni Mario, Contu Antonio, Tanda Francesco, Farris Antonio, Orrù Sandra, Floris Carlo, Pisano Marina, Lovicu Mario, Santona Maria Cristina, Landriscina Gennaro, Crisponi Laura, Palmieri Giuseppe, Monne Maria
Abstract excerpt
BACKGROUND: In recent years, numerous studies have assessed the prevalence of germline mutations in BRCA1 and BRCA2 genes in various cohorts. We here extensively investigated the prevalence and geographical distribution of BRCA1-2 mutations in the entire genetically-homogeneous Sardinian population. The occurrence of phenotypic characteristics which may be predictive for the presence of BRCA1-2 germline mutations...
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