Article
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting.
The Journal of molecular diagnostics : JMD - 1 Nov 2012
Ibáñez Mariam, Such Esperanza, Cervera José, Luna Irene, Gómez-Seguí Inés, López-Pavía María, Dolz Sandra, Barragán Eva, Fuster Oscar, Llop Marta, Rodríguez-Veiga Rebeca, Avaria Amparo, Oltra Silvestre, Senent M Leonor, Moscardó Federico, Montesinos Pau, Martínez-Cuadrón David, Martín Guillermo, Sanz Miguel A
Abstract excerpt
Recently, many novel molecular abnormalities were found to be distinctly associated with acute myeloid leukemia (AML). However, their clinical relevance and prognostic implications are not well established. We developed a new combination of high-resolution melting assays on a LightCycler 480 and direct sequencing to detect somatic mutations of ASXL1 (exon 12), IDH1 (exon 4), IDH2 (exon 4), and c-CBL (exons 8 and...
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