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Article

Rapid and reliable detection of IDH1 R132 mutations in acute myeloid leukemia using high-resolution melting curve analysis.

Clinical biochemistry - 1 Jul 2011

Lin Jiang, Qian Jun, Yao Dong-Ming, Li Yun, Yang Jing, Chen Qin, Chai Hai-yan, Xiao Gao-Fei, Xu Wen-rong

Abstract excerpt

OBJECTIVE: The mutations of isocitrate dehydrogenase 1 (IDH1) gene have been identified in a proportion of hematologic malignancies including acute myeloid leukemia (AML). The aim of the present study was to explore the reliability of the high-resolution melting analysis (HRMA) for the identification of IDH1 R132 mutations in AML. DESIGNS AND METHODS: We evaluated the sensitivity of HRMA in the detection of IDH1...

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Source

Identifiers

PMID: 21539821
DOI: 10.1016/j.clinbiochem.2011.04.014

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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