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Article

Detection of NPM1 exon 12 mutations and FLT3 - internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia.

Journal of hematology & oncology - 29 Jul 2008

Tan Angela Y C, Westerman David A, Carney Dennis A, Seymour John F, Juneja Surender, Dobrovic Alexander

Abstract excerpt

BACKGROUND: Molecular characterisation of normal karyotype acute myeloid leukemia (NK-AML) allows prognostic stratification and potentially can alter treatment choices and pathways. Approximately 45-60% of patients with NK-AML carry NPM1 gene mutations and are associated with a favourable clinica...

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Source

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Identifiers

PMID: 18664261
DOI: 10.1186/1756-8722-1-10
PMCID: PMC2517593

Genes

NPM1
FLT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18664261-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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