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Article

IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.

Annals of hematology - 1 Apr 2012

Lin Jiang, Yao Dong-ming, Qian Jun, Chen Qin, Qian Wei, Li Yun, Yang Jing, Wang Cui-zhu, Chai Hai-yan, Qian Zhen, Xiao Gao-fei, Xu Wen-rong

Abstract excerpt

The somatic mutations of isocitrate dehydrogenase genes (IDH1 and IDH2) have been identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 R140/R172 mutations by high resolution melting analysis and direct sequencing in Chinese patients with different myeloid malignancies including 198 acute myeloid leukemia (AML), 82 myelodysplastic syndrome (MDS), 85 chronic myeloid leukemia, and...

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Identifiers

PMID: 21997850
DOI: 10.1007/s00277-011-1352-7

Genes

IDH1
IDH2

Provenance

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