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Article

Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia an algorithmic approach using high-resolution melting curve analysis.

The Journal of molecular diagnostics : JMD - 1 Nov 2011

Patel Keyur P, Barkoh Bedia A, Chen Zhao, Ma Deqin, Reddy Neelima, Medeiros L Jeffrey, Luthra Rajyalakshmi

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations and polymorphism are reported in 5% to 15% of acute myeloid leukemia (AML) cases, with G105 and R132 of IDH1 and R140 and R172 of IDH2 known to be clinically significant. Current Sanger sequencing assays to detect IDH mutations are labor intensive and not cost effective for clinical testing of low-frequency mutations. Therefore, we developed clinical assays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

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Share to Sequence Analysis, DNA

Source

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Identifiers

PMID: 21889610
DOI: 10.1016/j.jmoldx.2011.06.004
PMCID: PMC3194054

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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