Functional modulation of parkin through physical interaction with SUMO‐1

Abstract excerpt

Parkinson disease (PD) is the second most common neurodegenerative disorder and is characterized by the extensive and progressive loss of dopaminergic neurons in the CNS substantia nigra pars compacta region. Mutations in the parkin gene, which encodes for E3 ubiquitin ligase, have been implicated in autosomal recessive juvenile parkinsonism, an early-onset and common familial form of PD. Although several parkin...

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