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Article

SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2021

Brosnan-Cashman Jacqueline A, Davis Christine M, Diplas Bill H, Meeker Alan K, Rodriguez Fausto J, Heaphy Christopher M

Abstract excerpt

Subsets of high-grade gliomas, including glioblastoma (GBM), are known to utilize the alternative lengthening of telomeres (ALT) pathway for telomere length maintenance. However, the telomere maintenance profile of one subtype of GBM-giant cell GBM-has not been extensively studied. Here, we investigated the prevalence of ALT, as well as ATRX and SMARCAL1 protein loss, in a cohort of classic giant cell GBM and GBM...

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PMID: 34103668
DOI: 10.1038/s41379-021-00841-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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