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Article

Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival.

Journal of neuropathology and experimental neurology - 1 Jul 2010

McDonald Kerrie L, McDonnell Julie, Muntoni Alessandra, Henson Jeremy D, Hegi Monika E, von Deimling Andreas, Wheeler Helen R, Cook Ray J, Biggs Michael T, Little Nicholas S, Robinson Bruce G, Reddel Roger R, Royds Janice A

Abstract excerpt

Patients with glioblastoma (GBM) have variable clinical courses, but the factors that underlie this heterogeneity are not understood. To determine whether the presence of the telomerase-independent alternative lengthening of telomeres (ALTs) mechanism is a significant prognostic factor for survival, we performed a retrospective analysis of 573 GBM patients. The presence of ALT was identified in paraffin sections...

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PMID: 20535033
DOI: 10.1097/NEN.0b013e3181e576cf

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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