Article

Dynamic behavior and ligand binding properties of the wild type dCK and its characterized gemcitabine-resistant variant: a bioinformatics and computational study

2022-06-02

Abstract excerpt

In order to control the cell proliferation in various types of cancers, gemcitabine as the analogue of deoxycytidine is being used to perturb the DNA synthesis. The main challenge in using gemcitabine includes resistance of some patients to this compound due to the genetic mutations on deoxycytidine kinase (dCK) that are found in a fraction of human population. Here, we investigated the dynamics behavior and ligan...

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Literature Corpus work: c2bbe451-8efe-5b2e-99b0-dcb13cf44a7f
DOI: 10.21203/rs.3.rs-1661054/v1

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