Article
DNA repair gene XRCC1 polymorphisms and bladder cancer risk.
BMC genetics - 10 Apr 2007
Sak Sei Chung, Barrett Jennifer H, Paul Alan B, Bishop D Timothy, Kiltie Anne E
Abstract excerpt
BACKGROUND: Cigarette smoking and chemical occupational exposure are the main known risk factors for bladder transitional cell carcinoma (TCC). Oxidative DNA damage induced by carcinogens present in these exposures requires accurate base excision repair (BER). The XRCC1 protein plays a crucial role in BER by acting as a scaffold for other BER enzymes. Variants in the XRCC1 gene might alter protein structure or...
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