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Article

Genetic association between PLTP gene polymorphisms and Alzheimer's disease in a Japanese population.

Dementia and geriatric cognitive disorders - 1 Jan 2010

Kuerban Bolati, Shibata Nobuto, Komatsu Miwa, Ohnuma Tohru, Arai Heii

Abstract excerpt

BACKGROUND/AIMS: A recent paper reported that the phospholipid transfer protein (PLTP) reduces phosphorylation of tau in human neuronal cells. In addition, patients with Alzheimer's disease (AD) have significantly higher levels of PLTP in brain tissue and significantly lower PLTP-mediated phospholipid transfer activity in cerebrospinal fluid. PLTP also affects apolipoprotein E (APOE) secretion from glial cells....

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Source

Identifiers

PMID: 20714154
DOI: 10.1159/000318855

Genes

PLTP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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