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Tau pathway-based gene analysis on PET identifies CLU and FYN in a Korean cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Yi Dahyun, Byun Min Soo, Park Jong-Ho, Kim Jong-Won, Jung Gijung, Ahn Hyejin, Lee Jun-Young, Lee Yun-Sang, Kim Yu Kyeong, Kang Koung Mi, Sohn Chul-Ho, Liu Shiwei, Huang Yen-Ning, Saykin Andrew J, Lee Dong Young, Nho Kwangsik

Abstract excerpt

INTRODUCTION: The influence of genetic variation on tau protein aggregation, a key factor in Alzheimer's disease (AD), remains not fully understood. We aimed to identify novel genes associated with brain tau deposition using pathway-based candidate gene association analysis in a Korean cohort. METHODS: We analyzed data for 146 older adults from the well-established Korean AD continuum cohort (Korean Brain Aging...

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Alzheimer Disease
Brain
Clusterin
Cohort Studies
Positron-Emission Tomography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-fyn

Republic of Korea

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Open in PubMed Open full text

Identifiers

PMID: 39625110
DOI: 10.1002/alz.14416
PMCID: PMC11848168

Genes

CLU
FYN
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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