Article
Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.
Neurobiology of aging - 1 Mar 2017
Zahratka Jeffrey A, Shao Yvonne, Shaw McKenzie, Todd Kaitlin, Formica Shane V, Khrestian Maria, Montine Thomas, Leverenz James B, Bekris Lynn M
Abstract excerpt
Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau, are a key pathologic feature of Alzheimer's disease (AD). Tau phosphorylation is under the control of multiple kinases and phosphatases, including Fyn. Previously, our group found an association between 2 regulatory single nucleotide polymorphisms in the FYN gene with increased tau levels in the cerebrospinal fluid. In this study, we...
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