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Article

The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.

Human molecular genetics - 15 Jun 2018

Tramarin Marco, Rusconi Laura, Pizzamiglio Lara, Barbiero Isabella, Peroni Diana, Scaramuzza Linda, Guilliams Tim, Cavalla David, Antonucci Flavia, Kilstrup-Nielsen Charlotte

Abstract excerpt

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a complex neurological disorder, characterized by infantile seizures, impairment of cognitive and motor skills and autistic features. Loss of Cdkl5 in mice affects dendritic spine maturation and dynamics but the underlying molecular mechanisms are still far from fully understood. Here we show that Cdkl5 deficiency in primary hippocampal...

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Source

Identifiers

PMID: 29618004
DOI: 10.1093/hmg/ddy108

Genes

CDKL5
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.PMID 29618004Read ↗

mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorderSemantic proximity Read ↗

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiologySemantic proximity Read ↗

Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorderSemantic proximity Read ↗

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.Semantic proximity Read ↗

Mosaic CDKL5 expression in heterozygous female mice is associated with age- and region- dependent remodeling of inhibitory circuitsSemantic proximity Read ↗

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.Semantic proximity Read ↗

Tau controls NMDA receptor trafficking during homeostatic synaptic plasticitySemantic proximity Read ↗

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.Semantic proximity Read ↗

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability.Semantic proximity Read ↗

Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domainsSemantic proximity Read ↗

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunitSemantic proximity Read ↗

Deficiency of cyclin-dependent kinase-like 5 causes spontaneous epileptic seizures in neonatal miceSemantic proximity Read ↗

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