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Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans

31 Jul 2024

Abstract excerpt

The ubiquitin-proteasome system (UPS) is critical for maintaining proteostasis, influencing stress resilience, lifespan, and thermal adaptability in organisms. In Caenorhabditis elegans, specific proteasome subunits and activators, such as RPN-6, PBS-6, and PSME-3, are associated with heat resistance, survival at cold (4°C), and enhanced longevity at moderate temperatures (15°C). Previously linked to improving...

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PMID: 39083540
DOI: 10.1371/journal.pgen.1011371

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