Article
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.
Genome research - 1 Nov 2012
Beyan Huriya, Down Thomas A, Ramagopalan Sreeram V, Uvebrant Kristina, Nilsson Anita, Holland Michelle L, Gemma Carolina, Giovannoni Gavin, Boehm Bernhard O, Ebers George C, Lernmark Åke, Cilio Corrado M, Leslie R David, Rakyan Vardhman K
Abstract excerpt
A major concern in common disease epigenomics is distinguishing causal from consequential epigenetic variation. One means of addressing this issue is to identify the temporal origins of epigenetic variants via longitudinal analyses. However, prospective birth-cohort studies are expensive and time consuming. Here, we report DNA methylomics of archived Guthrie cards for the retrospective longitudinal analyses of...
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