Article
The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.
Genome research - 1 Jul 2014
Teh Ai Ling, Pan Hong, Chen Li, Ong Mei-Lyn, Dogra Shaillay, Wong Johnny, MacIsaac Julia L, Mah Sarah M, McEwen Lisa M, Saw Seang-Mei, Godfrey Keith M, Chong Yap-Seng, Kwek Kenneth, Kwoh Chee-Keong, Soh Shu-E, Chong Mary F F, Barton Sheila, Karnani Neerja, Cheong Clara Y, Buschdorf Jan Paul, Stünkel Walter, Kobor Michael S, Meaney Michael J, Gluckman Peter D, Holbrook Joanna D
Abstract excerpt
Integrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins of a range of disorders. The quality of the in utero environment significantly influences health over the lifecourse. Epigenetics, and in particular DNA methylation marks, have been postulated as...
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