Article
How lifetimes shape epigenotype within and across generations.
Human molecular genetics - 15 Oct 2006
Whitelaw Nadia C, Whitelaw Emma
Abstract excerpt
Despite our detailed characterization of the human genome at the level of the primary DNA sequence, we are still far from understanding the molecular events underlying phenotypic variation. Epigenetic modifications to the DNA sequence and associated chromatin are known to regulate gene expression and, as such, are a significant contributor to phenotype. Studies of inbred mice and monozygotic twins show that...
Topics
- Animals
- Chromatin
- DNA Methylation
- DNA Replication
- Environment
- Epigenesis, Genetic
- Genotype
- Humans
- Mice
- Models, Genetic
- Phenotype
- Stochastic Processes