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Article

Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.

PLoS genetics - 1 Jan 2012

Petrakis Spyros, Raskó Tamás, Russ Jenny, Friedrich Ralf P, Stroedicke Martin, Riechers Sean-Patrick, Muehlenberg Katja, Möller Angeli, Reinhardt Anita, Vinayagam Arunachalam, Schaefer Martin H, Boutros Michael, Tricoire Hervé, Andrade-Navarro Miguel A, Wanker Erich E

Abstract excerpt

Proteins with long, pathogenic polyglutamine (polyQ) sequences have an enhanced propensity to spontaneously misfold and self-assemble into insoluble protein aggregates. Here, we have identified 21 human proteins that influence polyQ-induced ataxin-1 misfolding and proteotoxicity in cell model systems. By analyzing the protein sequences of these modifiers, we discovered a recurrent presence of coiled-coil (CC)...

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Identifiers

PMID: 22916034
DOI: 10.1371/journal.pgen.1002897
PMCID: PMC3420947

Genes

MED15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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