Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.

Molecular oncology - 1 Dec 2008

Bartkova Jirina, Tommiska Johanna, Oplustilova Lenka, Aaltonen Kirsimari, Tamminen Anitta, Heikkinen Tuomas, Mistrik Martin, Aittomäki Kristiina, Blomqvist Carl, Heikkilä Päivi, Lukas Jiri, Nevanlinna Heli, Bartek Jiri

Abstract excerpt

The MRE11, RAD50, and NBS1 genes encode proteins of the MRE11-RAD50-NBS1 (MRN) complex critical for proper maintenance of genomic integrity and tumour suppression; however, the extent and impact of their cancer-predisposing defects, and potential clinical value remain to be determined. Here, we report that among a large series of approximately 1000 breast carcinomas, around 3%, 7% and 10% tumours showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Anhydride Hydrolases
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to DNA Repair Enzymes

Share to Family Health

Share to Germ-Line Mutation

Share to MRE11 Homologue Protein

Share to Mutant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19383352
DOI: 10.1016/j.molonc.2008.09.007
PMCID: PMC5527773

Genes

MRE11
RAD50
BRCA1
ERBB2
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.PMID 19383352Read ↗

A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.Semantic proximity Read ↗

MRN Complex and Cancer Risk: Old Bottles, New Wine.Semantic proximity Read ↗

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer CellsSemantic proximity Read ↗

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN ComplexSemantic proximity Read ↗

DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN ComplexSemantic proximity Read ↗

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.Semantic proximity Read ↗

Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.Semantic proximity Read ↗

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.Semantic proximity Read ↗

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatmentSemantic proximity Read ↗

MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.Semantic proximity Read ↗

The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer.Semantic proximity Read ↗

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.