GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients

Abstract excerpt

BACKGROUND: In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of BMPs and their antagonist, and the fact that both promote tumor aggressiveness seems contradictory and is not fully understood. METHODS: We analyzed the transcriptomes of the metastatic 66cl4...

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