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Article

Mutagenesis by an antisense oligonucleotide and its degradation product.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2012

Reshat Reshat, Priestley Catherine C, Gooderham Nigel J

Abstract excerpt

The European Medicines Agency has expressed concern regarding (1) the potential for antisense oligonucleotide (ASO) therapeutics to induce sequence-specific mutation at genomic DNA and (2) the capability of ASO degradation products (nucleotide analogues) to incorporate into newly synthesized genomic DNA via DNA polymerase and cause mutation if base pairing occurs with reduced fidelity. Treating human...

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PMID: 22872057
DOI: 10.1093/toxsci/kfs247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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