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Article

Efficient binding of 4/7 α-conotoxins to nicotinic α4β2 receptors is prevented by Arg185 and Pro195 in the α4 subunit.

Molecular pharmacology - 1 Oct 2012

Beissner Mirko, Dutertre Sébastien, Schemm Rudolf, Danker Timm, Sporning Annett, Grubmüller Helmut, Nicke Annette

Abstract excerpt

α-Conotoxins are subtype-selective nicotinic acetylcholine receptor (nAChR) antagonists. Although potent α3β2 nAChR-selective α-conotoxins have been identified, currently characterized α-conotoxins show no or only weak affinity for α4β2 nAChRs, which are, besides α7 receptors, the most abundant n...

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Identifiers

PMID: 22802270
DOI: 10.1124/mol.112.078683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22802270-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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