Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clostridium difficile toxin synthesis is negatively regulated by TcdC

14 May 2008

Abstract excerpt

Clostridium difficile toxin synthesis is growth phase-dependent and is regulated by various environmental signals. The toxin genes tcdA and tcdB are located in a pathogenicity locus, which also includes three accessory genes, tcdR, tcdC and tcdE. TcdR has been shown to act as an alternative sigma factor that mediates positive regulation of both the toxin genes and its own gene. The tcdA, tcdB and tcdR genes are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clostridium difficile and Clostridium perfringens research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18480323
DOI: 10.1099/jmm.0.47775-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clostridium difficile toxin synthesis is negatively regulated by TcdCPMID 18480323Read ↗

<i>Clostridium difficile</i> toxin expression is inhibited by the novel regulator TcdCSemantic proximity Read ↗

TcdC Does Not Significantly Repress Toxin Expression in Clostridium difficile 630ΔErmSemantic proximity Read ↗

Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291Semantic proximity Read ↗

Comparison of toxin and spore production in clinically relevant strains of Clostridium difficileSemantic proximity Read ↗

CdtR Regulates TcdA and TcdB Production in Clostridium difficileSemantic proximity Read ↗

The Regulatory Networks That Control Clostridium difficile Toxin SynthesisSemantic proximity Read ↗

Human Hypervirulent Clostridium difficile Strains Exhibit Increased Sporulation as Well as Robust Toxin ProductionSemantic proximity Read ↗

Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates.Semantic proximity Read ↗

Transcription Analysis of the Genes <i>tcdA‐E</i> of the Pathogenicity Locus of <i>Clostridium Difficile</i>Semantic proximity Read ↗

Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China.Semantic proximity Read ↗

The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile.Semantic proximity Read ↗

Phase variation of Clostridium difficile virulence factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.