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Article

Interactions of early adversity with stress-related gene polymorphisms impact regional brain structure in females.

Brain structure & function - 1 Apr 2016

Gupta Arpana, Labus Jennifer, Kilpatrick Lisa A, Bonyadi Mariam, Ashe-McNalley Cody, Heendeniya Nuwanthi, Bradesi Sylvie, Chang Lin, Mayer Emeran A

Abstract excerpt

Early adverse life events (EALs) have been associated with regional thinning of the subgenual cingulate cortex (sgACC), a brain region implicated in the development of disorders of mood and affect, and often comorbid functional pain disorders, such as irritable bowel syndrome (IBS). Regional neuroinflammation related to chronic stress system activation has been suggested as a possible mechanism underlying these...

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Identifiers

PMID: 25630611
DOI: 10.1007/s00429-015-0996-9
PMCID: PMC4573367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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