Article
Overexpression of EGFR pathway-related genes in the circulation is highly correlated with EGFR mutations and overexpression in paired cancer tissue from patients with non-small cell lung cancer.
Oncology reports - 1 Mar 2010
Chen Chung-Chi, Chiu Hua-Hsien, Yen Li-Chen, Chang Hui-Jen, Chang Ming-Sung, Tsai Jong-Rung, Chen Yi-Fang, Lin Shiu-Ru
Abstract excerpt
Epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) have been established as a treatment option in patients with advanced non-small cell lung cancer (NSCLC). Clinically, PCR and RFLP are commonly used to evaluate the efficacy of TKIs, and these methods require cancer tissues to proceed. In the event a peripheral blood test is able to replace current evaluation methods, a greater...
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