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Article

Establishment of a Novel Method for Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance Mutations in Lung Cancer.

Chinese medical journal - 20 Jun 2017

Tian Hong-Xia, Zhang Xu-Chao, Wang Zhen, Yang Jin-Ji, Guo Wei-Bang, Chen Zhi-Hong, Wu Yi-Long

Abstract excerpt

BACKGROUND: Drug resistance to targeted therapies occurs in lung cancer, and resistance mechanisms related to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are continuously being discovered. We aimed to establish a novel method for highly parallel multiplexed detection of genetic mutations related to EGFR TKI-resistant lung cancer using Agena iPLEX chemistry and matrix-assisted laser...

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Topics

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28584208
DOI: 10.4103/0366-6999.207478
PMCID: PMC5463475

Genes

EGFR
KRAS
BRAF
ERBB2
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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