Article
[Detection of epidermal growth factor receptor mutations in non-small cell lung cancer tumor specimens from various ways by denaturing high-performance liquid chromatography].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 1 Sept 2010
Chen Siyuan, Chen Zhihong, Guo Ailin, Su Jian, Huang Ying, Chen Shiliang, Zhang Xuchao, Yang Xuening, Yang Jinji, Wu Yilong
Abstract excerpt
BACKGROUND AND OBJECTIVE: Epidermal growth factor receptor (EGFR) is the most important therapeutic target in non-small cell lung cancer (NSCLC). EGFR mutations may predict responsiveness to tyrosine kinase inhibitors (TKIs). These mutations are commonly identified using direct sequencing, which is considered the gold standard. But direct sequencing is time-consuming and hyposensitive. In addition, this method...
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