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Article

Peroxisome Proliferator-Activated Receptor Coactivator 1 in Caloric Restriction and Other Models of Longevity

1 Dec 2005

Abstract excerpt

Dietary restriction of calories (caloric restriction [CR]) increases longevity in phylogenetically diverse species. CR retards or prevents age-dependent deterioration of tissues and an array of spontaneous and chemically induced diseases associated with obesity including cardiovascular disease, diabetes, and cancer. An understanding of the molecular mechanisms that underlie the beneficial effects of CR will help...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 16424281
DOI: 10.1093/gerona/60.12.1494

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