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Article

Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape

4 Mar 2025

Abstract excerpt

Introduction: The HIV regulatory protein Tat enhances viral transcription and also modifies host gene expression, affecting cell functions like cell cycle and apoptosis. Residual expression of Tat protein is detected in blood and other tissues even under antiretroviral treatment. Cohort studies have indicated that, despite virologic suppression, people with HIV (PWH) are at increased risk of comorbidities linked...

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Identifiers

PMID: 40103825
DOI: 10.3389/fimmu.2025.1532692

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